2642218-07-1
Chemical Structure
HIV-1 inhibitor-28
- CAS No.: 2642218-07-1
- Formula:C26H32N6O3S
- Molecular Weight:508.64
IUPAC Name: 3,5-dimethyl-4-((2-((1-(2-morpholino-2-oxoethyl)piperidin-4-yl)amino)-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl)oxy)benzonitrile
InChIKey: WJCCYSICWXLYGV-UHFFFAOYSA-N
SMILES: CC1=CC(C#N)=CC(C)=C1OC2=C3SCCC3=NC(NC4CCN(CC4)CC(N5CCOCC5)=O)=N2
Biological Activity: HIV-1 inhibitor-28 (compound 14j2) is a highly potent and selective HIV-1 inhibitor with an EC50 of 58 nM for WT HIV-1 strain and an IC50 of 3.37 μM for HIV-1 WT reverse transcription (RT). HIV-1 inhibitor-28 exhibits relatively low cytotoxicity in MT-4 cells (CC50 = 38.6 μM). HIV-1 inhibitor-28 can be used for researching AIDS[1].
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HIV-1 inhibitor-28 | HIV-1 inhibitor-28 (compound 14j2) is a highly potent and selective HIV-1 inhibitor with an EC50 of 58 nM for WT HIV-1 strain and an IC50 of 3.37 μM for HIV-1 WT reverse transcription (RT). HIV-1 inhibitor-28 exhibits relatively low cytotoxicity in MT-4 cells (CC50 = 38.6 μM). HIV-1 inhibitor-28 can be used for researching AIDS. | |||||||||||||||||||||
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Keywords
