2642233-93-8
2642233-93-8
Chemical Structure
AIM-1290
- CAS No.: 2642233-93-8
- Formula:C18H21F2N3O2S
- Molecular Weight:381.44
InChIKey: RPGKIKHEBZDURC-UHFFFAOYSA-N
SMILES: O=C(CCCN1CCOCCC1)NC2=CN=C(C3=C(F)C=C(F)C=C3)S2
Biological Activity: AIM-1290 is a PfFPPS/GGPPS inhibitor with an IC50 of 1.94 μM. AIM-1290 inhibits GGPP production by the bifunctional Plasmodium falciparum farnesyl/geranylgeranyl diphosphate synthase. AIM-1290 inhibits blood-stage Plasmodium falciparum growth. AIM-1290 shows in vitro ADME properties and a mouse pharmacokinetic profile. AIM-1290 can be used for the research of malaria[1].
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AIM-1290 | AIM-1290 is a PfFPPS/GGPPS inhibitor with an IC50 of 1.94 μM. AIM-1290 inhibits GGPP production by the bifunctional Plasmodium falciparum farnesyl/geranylgeranyl diphosphate synthase. AIM-1290 inhibits blood-stage Plasmodium falciparum growth. AIM-1290 shows in vitro ADME properties and a mouse pharmacokinetic profile. AIM-1290 can be used for the research of malaria. | |||||||||||||||||||||
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