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Cat. No.: HY-190087

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AIM-1290

AIM-1290 is a PfFPPS/GGPPS inhibitor with an IC₅₀ of 1.94 μM. AIM-1290 inhibits GGPP production by the bifunctional Plasmodium falciparum farnesyl/geranylgeranyl diphosphate synthase. AIM-1290 inhibits blood-stage Plasmodium falciparum growth. AIM-1290 shows in vitro ADME properties and a mouse pharmacokinetic profile. AIM-1290 can be used for the research of malaria.

For research use only. We do not sell to patients.

CAS No.: 2642233-93-8
Formula: C₁₈H₂₁F₂N₃O₂S
Molecular Weight:381.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

AIM-1290 Chemical Structure

CAS No.: 2642233-93-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Parasite Isoforms :

In Vitro

Parasitic InfectionOthers

Parasitic Infection

AIM-1290 (0.074 µM) inhibits the growth of blood-stage Plasmodium falciparum, with an IC₅₀ of 0.074 µM^[1].

Others

AIM-1290 (1.94 µM) inhibits purified PfFPPS/GGPPS-mediated GGPP production with an IC₅₀ of 1.94 µM^[1].
AIM-1290 (up to 200 µM) shows no inhibition of HsFPPS or HsGGPPS at concentrations up to 200 µM in project selectivity counter-screens^[1].
The human liver microsomal clearance of AIM-1290 is < 1 µL/min/mg, and its mouse liver microsomal clearance is 22 µL/min/mg^[1].
The LLC-PK1-MDR1 P_app of AIM-1290 is 92 nm/s, with an efflux ratio of 1.5^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Protocol for Pharmacokinetic Study

Chemical Information

CAS No. 2642233-93-8
Molecular Weight 381.44
Formula C₁₈H₂₁F₂N₃O₂S
SMILES

O=C(CCCN1CCOCCC1)NC2=CN=C(C3=C(F)C=C(F)C=C3)S2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kabeche S, et al. Nonbisphosphonate inhibitors of Plasmodium falciparum FPPS/GGPPS. Bioorganic & medicinal chemistry letters. 2021 Jun 01;41:127978. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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