26581-83-9
26581-83-9
Chemical Structure
2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe
- CAS No.: 26581-83-9
- Formula:C14H14N2O3
- Molecular Weight:258.27
IUPAC Name: 1-methyl-3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione
InChIKey: QURCPEBFVWXUKY-UHFFFAOYSA-N
SMILES: O=C1C2=C(CN1C3C(N(C)C(CC3)=O)=O)C=CC=C2
Biological Activity: 2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe is an E3 ligase ligand of SIAIS630121-NC (HY-159016). 2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe contains an extra methyl group on the glutarimide moiety of thalidomide, which is known to abrogate its ability to bind the E3 ligase CRBN. SIAIS630121-NC is a negative control for NAMPT degrader SIAIS630121[1].
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2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe | 2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe is an E3 ligase ligand of SIAIS630121-NC (HY-159016). 2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe contains an extra methyl group on the glutarimide moiety of thalidomide, which is known to abrogate its ability to bind the E3 ligase CRBN. SIAIS630121-NC is a negative control for NAMPT degrader SIAIS630121. | |||||||||||||||||||||
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References
