2667053-18-9
Chemical Structure
MAT2A-IN-1
- CAS No.: 2667053-18-9
- Formula:C29H28F2N6O4
- Molecular Weight:562.57
IUPAC Name: 8-(4-(difluoromethoxy)phenyl)-2-ethoxy-6-(2-(2-morpholinoethyl)-2H-indazol-5-yl)pyrido[2,3-d]pyrimidin-7(8H)-one
InChIKey: JDGDQZFQCHISCT-UHFFFAOYSA-N
SMILES: O=C1C(C2=CC3=CN(CCN4CCOCC4)N=C3C=C2)=CC5=C(N1C6=CC=C(C=C6)OC(F)F)N=C(OCC)N=C5
Biological Activity: MAT2A-IN-1 is a potent inhibitor of MAT2A. The expression level of MAT2A is abnormally high in several types of tumors, including gastric, colon, liver and pancreatic cancers. MAT2A-IN-1 reduces the proliferative activity of MTAP-deficient cancer cells. MAT2A-IN-1 has the potential for the research of cancer diseases (extracted from patent WO2021139775A1, compound 64)[1].
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MAT2A-IN-1 | MAT2A-IN-1 is a potent inhibitor of MAT2A. The expression level of MAT2A is abnormally high in several types of tumors, including gastric, colon, liver and pancreatic cancers. MAT2A-IN-1 reduces the proliferative activity of MTAP-deficient cancer cells. MAT2A-IN-1 has the potential for the research of cancer diseases (extracted from patent WO2021139775A1, compound 64). | |||||||||||||||||||||
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