27127-62-4
Chemical Structure
Viscosin
- CAS No.: 27127-62-4
- Formula:C54H95N9O16
- Molecular Weight:1126.40
IUPAC Name: (R)-5-(((3S,6R,9S,12R,15S,18R,21R,22R)-3-((S)-sec-butyl)-6,12-bis(hydroxymethyl)-9,15-diisobutyl-18-isopropyl-22-methyl-2,5,8,11,14,17,20-heptaoxo-1-oxa-4,7,10,13,16,19-hexaazacyclodocosan-21-yl)amino)-4-((S)-2-((R)-3-hydroxydecanamido)-4-methylpentanamido)-5-oxopentanoic acid
InChIKey: QYEWAEAWMXRMHB-YFTUCIGFSA-N
SMILES: N(C([C@H](NC([C@@H](NC(C[C@@H](CCCCCCC)O)=O)CC(C)C)=O)CCC(O)=O)=O)[C@H]1C(=O)N[C@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CO)C(=O)N[C@@]([C@H](CC)C)(C(=O)O[C@@H]1C)[H]
Biological Activity: Viscosin is a cyclic lipopeptide compound produced by the Pseudomonas genus. Viscosin exerts its antibacterial effect through two mechanisms: membrane permeabilization and interference with cell wall synthesis. Viscosin shows significant antibacterial activity against various Gram-positive bacteria, but has no inhibitory effect on fungi. Viscosin can be used for the study of bacterial infections[1][2].
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Viscosin | Viscosin is a cyclic lipopeptide compound produced by the Pseudomonas genus. Viscosin exerts its antibacterial effect through two mechanisms: membrane permeabilization and interference with cell wall synthesis. Viscosin shows significant antibacterial activity against various Gram-positive bacteria, but has no inhibitory effect on fungi. Viscosin can be used for the study of bacterial infections. | |||||||||||||||||||||
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- [1]. Winther AR, et al. Decreased susceptibility to viscosin in Streptococcus pneumoniae. Microbiol Spectr. 2024 Aug 6;12(8):e0062424. [Content Brief]
- [2]. Geudens N, et al. Membrane Interactions of Natural Cyclic Lipodepsipeptides of the Viscosin Group. Biochim Biophys Acta Biomembr. 2017 Mar;1859(3):331-339. [Content Brief]
Keywords