2720674-71-3
2720674-71-3
Chemical Structure
MAGL-IN-22
- CAS No.: 2720674-71-3
- Formula:C22H20FNO3
- Molecular Weight:365.40
SMILES: O=C(CCCC1=CC=CC=C1)NC2=C(C=CC(C3=CC(F)=C(C=C3)O)=C2)O
Biological Activity: MAGL-IN-22 (Compound 40) is a reversible, competitive, selective and BBB-penetrable MAGL inhibitor with an IC50 of 0.34 μM for hMAGL. MAGL-IN-22 has significant antioxidant and anti-inflammatory activity, and activates the Nrf2 pathway and significantly inhibits NFκB-mediated inflammation, without inducing cytotoxic effects. MAGL-IN-22 can be used for neurodegenerative diseases, chronic pain and cancers research[1].
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MAGL-IN-22 | MAGL-IN-22 (Compound 40) is a reversible, competitive, selective and BBB-penetrable MAGL inhibitor with an IC50 of 0.34 μM for hMAGL. MAGL-IN-22 has significant antioxidant and anti-inflammatory activity, and activates the Nrf2 pathway and significantly inhibits NFκB-mediated inflammation, without inducing cytotoxic effects. MAGL-IN-22 can be used for neurodegenerative diseases, chronic pain and cancers research. | |||||||||||||||||||||
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