276702-15-9
276702-15-9
Chemical Structure
SB-332235
- CAS No.: 276702-15-9
- Formula:C13H10Cl3N3O4S
- Molecular Weight:410.66
IUPAC Name: 6-chloro-3-(3-(2,3-dichlorophenyl)ureido)-2-hydroxybenzenesulfonamide
InChIKey: WTLRWOHEKQGKDS-UHFFFAOYSA-N
SMILES: O=S(C1=C(Cl)C=CC(NC(NC2=CC=CC(Cl)=C2Cl)=O)=C1O)(N)=O
Biological Activity: SB-332235 is a potent, orally active nonpeptide CXCR2 antagonist, with an IC50 of 7.7 nM. SB-332235 displays 285-fold selectivity for CXCR2 over CXCR1. SB-332235 inhibits acute and chronic models of arthritis in the rabbit. SB-332235 inhibits viability of AML cells[1][2].
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SB-332235 | 98.7% | SB-332235 is a potent, orally active nonpeptide CXCR2 antagonist, with an IC50 of 7.7 nM. SB-332235 displays 285-fold selectivity for CXCR2 over CXCR1. SB-332235 inhibits acute and chronic models of arthritis in the rabbit. SB-332235 inhibits viability of AML cells. | ||||||||||||||||||||
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References
- [1]. Podolin PL, et al. A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit. J Immunol. 2002;169(11):6435-6444. [Content Brief]
- [2]. Schinke C, et al. IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells [published correction appears in Blood. 2015 Jul 16;126(3):425. Barreryo, Laura [corrected to Barreyro, Laura]]. Blood. 2015;125(20):3144-3152. [Content Brief]
