SB-332235

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SB-332235 is a potent, orally active nonpeptide CXCR2 antagonist, with an IC₅₀ of 7.7 nM. SB-332235 displays 285-fold selectivity for CXCR2 over CXCR1. SB-332235 inhibits acute and chronic models of arthritis in the rabbit. SB-332235 inhibits viability of AML cells.

For research use only. We do not sell to patients.

SB-332235 Chemical Structure

CAS No. : 276702-15-9

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References
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Description

In Vitro

SB-332235 (1-100 μM; 48 hours) inhibits viability of AML cell lines^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	AML cell
Concentration:	1, 10, 100 μM
Incubation Time:	48 hours
Result:	Led to a dose-dependent decrease in proliferation in all cell lines.

In Vivo

SB-332235 (25 mg/kg, p.o., b.i.d.) exhibits significantly reduced numbers of total leukocytes in synovial fluids from IL-8-injected knees^[1].
SB-332235 (10-25 mg/kg; p.o.; twice a day for 14 days) inhibits chronic Ag-induced arthritis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult female New Zealand White rabbits (chronic OVA-induced model of arthritis)^[1]
Dosage:	10, 25 mg/kg
Administration:	P.o.; twice a day for 14 days
Result:	Day-15 synovial fluid leukocyte numbers in OVA-injected knees were significantly reduced in rabbits. The decrease in neutrophils, monocytes, and lymphocytes resulting from treatment with 25 mg/kg of the antagonist was accompanied by a significant reduction in synovial fluid PGE2, LTB4, LTC4, and IL-8 levels.

Molecular Weight

410.66

Formula

C₁₃H₁₀Cl₃N₃O₄S

CAS No.

276702-15-9

SMILES

O=S(C1=C(Cl)C=CC(NC(NC2=CC=CC(Cl)=C2Cl)=O)=C1O)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Podolin PL, et al. A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit. J Immunol. 2002;169(11):6435-6444. [Content Brief]

[2]. Schinke C, et al. IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells [published correction appears in Blood. 2015 Jul 16;126(3):425. Barreryo, Laura [corrected to Barreyro, Laura]]. Blood. 2015;125(20):3144-3152. [Content Brief]

SB-332235 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB-332235276702-15-9SB332235SB 332235CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsselectiveacutechronicarthritisAMLcellsleukocytesInhibitorinhibitorinhibit

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