1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. SB-332235

SB-332235 

Cat. No.: HY-16981
Handling Instructions

SB-332235 is a potent, orally active nonpeptide CXCR2 antagonist, with an IC50 of 7.7 nM. SB-332235 displays 285-fold selectivity for CXCR2 over CXCR1. SB-332235 inhibits acute and chronic models of arthritis in the rabbit. SB-332235 inhibits viability of AML cells.

For research use only. We do not sell to patients.

SB-332235 Chemical Structure

SB-332235 Chemical Structure

CAS No. : 276702-15-9

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Description

SB-332235 is a potent, orally active nonpeptide CXCR2 antagonist, with an IC50 of 7.7 nM. SB-332235 displays 285-fold selectivity for CXCR2 over CXCR1. SB-332235 inhibits acute and chronic models of arthritis in the rabbit. SB-332235 inhibits viability of AML cells[1][2].

In Vitro

SB-332235 (1-100 μM; 48 hours) inhibits viability of AML cell lines[2].

Cell Viability Assay[2]

Cell Line: AML cell
Concentration: 1, 10, 100 μM
Incubation Time: 48 hours
Result: Led to a dose-dependent decrease in proliferation in all cell lines.
In Vivo

SB-332235 (25 mg/kg, p.o., b.i.d.) exhibits significantly reduced numbers of total leukocytes in synovial fluids from IL-8-injected knees[1].
SB-332235 (10-25 mg/kg; p.o.; twice a day for 14 days) inhibits chronic Ag-induced arthritis[1].

Animal Model: Adult female New Zealand White rabbits (chronic OVA-induced model of arthritis)[1]
Dosage: 10, 25 mg/kg
Administration: P.o.; twice a day for 14 days
Result: Day-15 synovial fluid leukocyte numbers in OVA-injected knees were significantly reduced in rabbits. The decrease in neutrophils, monocytes, and lymphocytes resulting from treatment with 25 mg/kg of the antagonist was accompanied by a significant reduction in synovial fluid PGE2, LTB4, LTC4, and IL-8 levels.
Molecular Weight

410.66

Formula

C₁₃H₁₀Cl₃N₃O₄S

CAS No.

276702-15-9

SMILES

O=S(C1=C(Cl)C=CC(NC(NC2=CC=CC(Cl)=C2Cl)=O)=C1O)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SB-332235SB332235SB 332235CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsselectiveacutechronicarthritisAMLcellsleukocytesInhibitorinhibitorinhibit

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SB-332235
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HY-16981
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