2769141-82-2
Chemical Structure
SR-1114
- CAS No.: 2769141-82-2
- Formula:C39H42N8O11S
- Molecular Weight:830.86
IUPAC Name: 3-(3-methoxyphenyl)-1H-pyrazole-4-carbaldehyde
InChIKey: WPVVPCVQEBQVLL-UHFFFAOYSA-N
SMILES: O=C(NCCOCCOCCNS(=O)(NC1=CC=CC(C2=CN3C=C(C=CC3=N2)C(NC4CCC4)=O)=C1)=O)COC5=CC=CC6=C5C(N(C6=O)C7CCC(NC7=O)=O)=O
Biological Activity: SR-1114 is a ENL PROTAC degrader, with DC50 values of 150 nM, 311 nM and 1.65 μM in MV4;11, MOLM-13 and OCI/AML-2 cells, respectively. SR-1114 has an IC50 of 155 nM against the human CRL4CRBN complex. SR-1114 can be used in research related to acute leukemia and acute myeloid leukemia[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SR-1114 | 98.22% | SR-1114 is a ENL PROTAC degrader, with DC50 values of 150 nM, 311 nM and 1.65 μM in MV4;11, MOLM-13 and OCI/AML-2 cells, respectively. SR-1114 has an IC50 of 155 nM against the human CRL4CRBN complex. SR-1114 can be used in research related to acute leukemia and acute myeloid leukemia. | ||||||||||||||||||||
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- [1]. Garnar-Wortzel L, et al. Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia. ACS central science. 2021 May 26;7(5):815-830. [Content Brief]
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[2]. Shaum JB, et al. High-throughput ligand diversification to discover chemical inducers of proximity. Nat Chem Biol. 2026 Feb 16:10.1038/s41589-025-02137-2.
[Content Brief]
Keywords
