2796282-49-8
2796282-49-8
Chemical Structure
HDAC6-IN-8
- CAS No.: 2796282-49-8
- Formula:C23H17BrFN5O3
- Molecular Weight:510.32
IUPAC Name: 4-(2-((4-((4-bromo-3-fluorophenyl)amino)quinazolin-6-yl)amino)-2-oxoethyl)-N-hydroxybenzamide
InChIKey: LPGXGACITWQHMB-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C2N=CN=C(C2=C1)NC3=CC(F)=C(C=C3)Br)CC4=CC=C(C=C4)C(NO)=O
Biological Activity: A variety of compounds were designed and synthesized by modifying cap groups. The enzyme inhibition test showed that compound 12C had broad-spectrum enzyme inhibitory activity, and compounds 9m and 9q were more inclined to inhibit HDAC6, showing a certain selective inhibitory activity among the representative subtypes.
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HDAC6-IN-8 | A variety of compounds were designed and synthesized by modifying cap groups. The enzyme inhibition test showed that compound 12C had broad-spectrum enzyme inhibitory activity, and compounds 9m and 9q were more inclined to inhibit HDAC6, showing a certain selective inhibitory activity among the representative subtypes. | |||||||||||||||||||||
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