2809982-20-3
2809982-20-3
Chemical Structure
EGFR-IN-132
- CAS No.: 2809982-20-3
- Formula:C27H31N7O3
- Molecular Weight:501.58
SMILES: C[C@H]1CN2C3=CC=C(NC4COC4)C=C3N/C2=N\C(C5=CC(C)=NC(C6=C(N(N=C6)C)OCCC1)=C5)=O
Biological Activity: EGFR-IN-132 (Compound 23) is an inhibitor for EGFR, that inhibits the EGFR wildtype, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S mutans with IC50 of 1.6, 0.025, 0.019, 0.022, and 0.029 nM. EGFR-IN-132 exhibits good pharmacokinetics characteristics with high oral exposure[1].
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EGFR-IN-132 | EGFR-IN-132 (Compound 23) is an inhibitor for EGFR, that inhibits the EGFR wildtype, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S mutans with IC50 of 1.6, 0.025, 0.019, 0.022, and 0.029 nM. EGFR-IN-132 exhibits good pharmacokinetics characteristics with high oral exposure. | |||||||||||||||||||||
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