EGFR-IN-132
EGFR-IN-132 (Compound 23) is an inhibitor for EGFR, that inhibits the EGFR wildtype, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S mutans with IC50 of 1.6, 0.025, 0.019, 0.022, and 0.029 nM. EGFR-IN-132 exhibits good pharmacokinetics characteristics with high oral exposure.
For research use only. We do not sell to patients.
- CAS No.: 2809982-20-3
- Formula: C27H31N7O3
- Molecular Weight:501.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All EGFR Isoforms
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Biological Activity
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EGFR (WT) 1.6 nM (IC50) |
Chemical Information
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CAS No. 2809982-20-3
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Molecular Weight 501.58
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Formula C27H31N7O3
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SMILES
C[C@H]1CN2C3=CC=C(NC4COC4)C=C3N/C2=N\C(C5=CC(C)=NC(C6=C(N(N=C6)C)OCCC1)=C5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)