2845151-86-0

Polfurmetinib Chemical Structure
2845151-86-0

Chemical Structure

Polfurmetinib

Synonym(s): MEK-IN-6

  • CAS No.: 2845151-86-0
  • Formula:C18H20FN3O4S
  • Molecular Weight:393.43

IUPAC Name: 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione

InChIKey: TURWFFGYNJNSFK-UHFFFAOYSA-N

SMILES: O=C1C=C2C(C(N(CC2)OCCO)=O)=C(N1C)NC3=CC=C(C=C3F)SC

Biological Activity: Polfurmetinib (MEK-IN-6) (Example 69) is a MEK inhibitor. MEK-IN-6 inhibits ERK1/2 (Thr202/Tyr204) phosphorylation in A375 cells (IC50: 2 nM). Polfurmetinib can be used for research of cancer[1].

Cat. No. Product Name Purity Description Pricing
HY-153445 		Polfurmetinib 98.21% Polfurmetinib (MEK-IN-6) (Example 69) is a MEK inhibitor. MEK-IN-6 inhibits ERK1/2 (Thr202/Tyr204) phosphorylation in A375 cells (IC50: 2 nM). Polfurmetinib can be used for research of cancer.
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