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Cat. No.: HY-153445A

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Polfurmetinib hydrate

(Synonyms: MEK-IN-6 hydrate)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Polfurmetinib (MEK-IN-6) hydrate (compound 69) is a MEK inhibitor. Polfurmetinib hydrate has an IC₅₀ of 2 nM for A375 cells.

For research use only. We do not sell to patients.

CAS No.: 2845153-35-5
Formula: C₁₈H₂₂FN₃O₅S
Molecular Weight:411.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Polfurmetinib hydrate Chemical Structure

CAS No.: 2845153-35-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Polfurmetinib (MEK-IN-6) hydrate (compound 69) is a MEK inhibitor. Polfurmetinib hydrate has an IC₅₀ of 2 nM for A375 cells^[1].

IC₅₀ & Target^[1]

MEK

All MEK Isoforms :

Chemical Information

CAS No. 2845153-35-5
Molecular Weight 411.45
Formula C₁₈H₂₂FN₃O₅S
SMILES

O=C1C=C2C(C(N(CC2)OCCO)=O)=C(N1C)NC3=CC=C(C=C3F)SC.O
Synonyms

MEK-IN-6 hydrate
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

Phytomedicine

Guggulsterone suppresses osteosarcoma progression by inhibiting glycolysis through MAPK signaling pathway. [Abstract]

2025 Aug:144:156949. PMID: 40517691

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shelley Allen, et al. 3,4-dihydro-2,7-naphthyridine-1,6(2h,7h)-diones as mek inhibitors. WO2022208391A1.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Polfurmetinib hydrate

1 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (1)
Purity & Documentation
References

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Polfurmetinib hydrate

Publications Citing Use of MedChemExpress (MCE) Polfurmetinib hydrate

All MEK Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

Polfurmetinib hydrate Related Classifications

HY-153445A Related Classifications