Polfurmetinib hydrate
Based on 1 publication(s) in Google Scholar
Polfurmetinib hydrate (MEK-IN-6 hydrate) is a MEK inhibitor and inhibits ERK1/2 phosphorylation in A375 cells. Polfurmetinib hydrate can be used for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 2845153-35-5
- Formula: C18H22FN3O5S
- Molecular Weight:411.45
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Polfurmetinib hydrate
MoreAll MEK Isoforms
More
Biological Activity
Description
IC50 & Target
[1]|
MEK |
ERK1 |
ERK2 |
In Vitro
Polfurmetinib hydrate (Compound 69) inhibits ERK1/2 phosphorylation in A375 cells with IC50 = 2 nM[1].
Polfurmetinib hydrate exhibits high membrane permeability with a Papp = 19.6 × 10‑6 cm/s and an efflux ratio of 2.3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2845153-35-5
-
Molecular Weight 411.45
-
Formula C18H22FN3O5S
-
SMILES
O=C1C=C2C(C(N(CC2)OCCO)=O)=C(N1C)NC3=CC=C(C=C3F)SC.O
-
Synonyms
MEK-IN-6 hydrate
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Phytomedicine
Guggulsterone suppresses osteosarcoma progression by inhibiting glycolysis through MAPK signaling pathway. [Abstract]2025 Aug:144:156949. PMID: 40517691
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Polfurmetinib hydrate Related Classifications
HY-153445A Related Classifications
Powered by Bioz