288246-59-3
288246-59-3
Chemical Structure
ITI-367
- CAS No.: 288246-59-3
- Formula:C16H11F3N2O3
- Molecular Weight:336.27
InChIKey: LQWTVDHYWXZDHM-UHFFFAOYSA-N
SMILES: O=C1ON=C(N1C2=CC=CC(C(F)(F)F)=C2)C3=C(OC)C=CC=C3
Biological Activity: ITI-367 is a HIV-1 inhibitor that targets the nuclear localization signal 1 (NLS-1) of HIV-1 matrix protein and the interaction between HIV-1 pre-integration complex (PIC) and importin-β. ITI-367 inhibits HIV-1 replication at the pre-integration stage, reduces the formation of 2-LTR circles, and sequesters viral DNA in the cytoplasm. ITI-367 can be used for the research of HIV infection[1].
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ITI-367 | ITI-367 is a HIV-1 inhibitor that targets the nuclear localization signal 1 (NLS-1) of HIV-1 matrix protein and the interaction between HIV-1 pre-integration complex (PIC) and importin-β. ITI-367 inhibits HIV-1 replication at the pre-integration stage, reduces the formation of 2-LTR circles, and sequesters viral DNA in the cytoplasm. ITI-367 can be used for the research of HIV infection. | |||||||||||||||||||||
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References
Keywords
