2. Anti-infection
  3. HIV
  4. ITI-367

ITI-367 is a HIV-1 inhibitor that targets the nuclear localization signal 1 (NLS-1) of HIV-1 matrix protein and the interaction between HIV-1 pre-integration complex (PIC) and importin-β. ITI-367 inhibits HIV-1 replication at the pre-integration stage, reduces the formation of 2-LTR circles, and sequesters viral DNA in the cytoplasm. ITI-367 can be used for the research of HIV infection.

For research use only. We do not sell to patients.

ITI-367

ITI-367 Chemical Structure

CAS No. : 288246-59-3

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Description

ITI-367 is a HIV-1 inhibitor that targets the nuclear localization signal 1 (NLS-1) of HIV-1 matrix protein and the interaction between HIV-1 pre-integration complex (PIC) and importin-β. ITI-367 inhibits HIV-1 replication at the pre-integration stage, reduces the formation of 2-LTR circles, and sequesters viral DNA in the cytoplasm. ITI-367 can be used for the research of HIV infection[1].

In Vitro

ITI-367 (10 μM) specifically inhibits HIV-1 replication in CEM CD4+ T lymphocytes without affecting HTLV-I replication[1].
ITI-367 (0-10 μM) inhibits HIV-1 ADA replication in primary monocyte-derived macrophages in a dose-dependent manner, with an IC50 of 0.05 μM[1].
ITI-367 (0-10 μM) inhibits HIV-1 M1 replication in tonsil-derived primary T lymphocytes in a dose-dependent manner, with an IC50 of 0.7 μM[1].
ITI-367 (0-1 μM; 3 h pre-infection, 12 days post-infection) inhibits the replication of HIV-1 LAI and HIV-1 SF-162 in cultured human tonsillar lymphoid tissues in vitro in a dose-dependent manner without inducing cytotoxicity[1].
ITI-367 (0-10 μM; 8 days post-infection) targets MA NLS-1 to inhibit viral replication in primary monocyte-derived macrophages[1].
ITI-367 (0-10 μM; 2 h) dose-dependently inhibits the binding of HIV-1 PICs to human importin α in cytoplasmic fractions derived from Jurkat cells[1].
ITI-367 (1 μM; 72 h) specifically inhibits HIV-1 nuclear translocation in primary monocyte-derived macrophages[1].
ITI-367 (10 μM; 2 h pre-incubation, 72 h post-infection) inhibits the nuclear translocation of HIV-1 DNA in primary monocyte-derived macrophages[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ITI-367 Related Antibodies

Real Time qPCR[1]

Cell Line: primary monocyte-derived macrophages
Concentration: 1 μM
Incubation Time: 72 h post-infection
Result: Dramatically reduced the amount of 2-LTR circle forms (a marker of nuclear import).
Did not affect the amount of late reverse transcripts (a marker of reverse transcription).

Immunofluorescence[1]

Cell Line: primary monocyte-derived macrophages
Concentration: 10 μM
Incubation Time: 2 h pre-incubation; 72 h post-infection
Result: Resulted in substantially less nuclei-localized fluorescent HIV-1 DNA compared to untreated cells, with viral DNA retained in the cytoplasm.
Molecular Weight

336.27

Formula

C16H11F3N2O3
CAS No.
SMILES

O=C1ON=C(N1C2=CC=CC(C(F)(F)F)=C2)C3=C(OC)C=CC=C3
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References
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ITI-367 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ITI-367288246-59-3ITI367ITI 367HIVHuman immunodeficiency virusimportin-βCEM CD4+ T lymphocytesHTLV-IHIV-1 preintegration complex (PIC)primary monocyte-derived macrophagesJurkat cell-derived cytosolic fractionstonsil-derived primary T lymphocytesHIV-1 matrix protein (MA)nuclear localization signal 1 (NLS-1)human tonsil lymphoid tissueInhibitorinhibitorinhibit

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