2883403-42-5
Chemical Structure
Topoisomerase IV inhibitor 1
- CAS No.: 2883403-42-5
- Formula:C34H32FN7O6S
- Molecular Weight:685.72
IUPAC Name: 1-cyclopropyl-6-fluoro-4-oxo-7-(4-(3-oxo-3-((4-(N-(quinoxalin-2-yl)sulfamoyl)phenyl)amino)propyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
InChIKey: ZQRZCLVUOLDFJC-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(C=C1)S(=O)(NC2=NC3=C(N=C2)C=CC=C3)=O)CCN4CCN(CC4)C5=CC6=C(C(C(C(O)=O)=CN6C7CC7)=O)C=C5F
Biological Activity: Topoisomerase IV inhibitor 2 (compound 7d) is a potent DNA topoisomerase IV (TOPO IV) inhibitor with IC50s of 0.23 μM and 0.43 μM for TOPO IV and DNA gyrase, respectively. Topoisomerase IV inhibitor 2 has anti-bacterial activity, with MICs of 0.972 μM and 0.608 μM in Staphylococcus aureus Newman and Escherichia coli ATCC8739, respectively[1].
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Topoisomerase IV inhibitor 1 | Topoisomerase IV inhibitor 2 (compound 7d) is a potent DNA topoisomerase IV (TOPO IV) inhibitor with IC50s of 0.23 μM and 0.43 μM for TOPO IV and DNA gyrase, respectively. Topoisomerase IV inhibitor 2 has anti-bacterial activity, with MICs of 0.972 μM and 0.608 μM in Staphylococcus aureus Newman and Escherichia coli ATCC8739, respectively. | |||||||||||||||||||||
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Keywords
