2913151-46-7
2913151-46-7
Chemical Structure
ASM-IN-1
- CAS No.: 2913151-46-7
- Formula:C16H12BrN3O4
- Molecular Weight:390.19
IUPAC Name: 3-(4-((4-bromophenoxy)methyl)phenyl)-N-hydroxy-1,2,4-oxadiazole-5-carboxamide
InChIKey: YYAPAXZETRKZHT-UHFFFAOYSA-N
SMILES: BrC1=CC=C(OCC2=CC=C(C3=NOC(C(NO)=O)=N3)C=C2)C=C1
Biological Activity: ASM-IN-1 is a potent and orally active acid sphingomyelinase (ASM) inhibitor with an IC50 value of 1.5 µM. ASM-IN-1 reduces lipid plaques in the aortic arch and aorta and reduces plasma ceramide concentration and Ox-LDL levels. ASM-IN-1 shows antiatherosclerotic and anti-inflammatory activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ASM-IN-1 | 98.65% | ASM-IN-1 is a potent and orally active acid sphingomyelinase (ASM) inhibitor with an IC50 value of 1.5 µM. ASM-IN-1 reduces lipid plaques in the aortic arch and aorta and reduces plasma ceramide concentration and Ox-LDL levels. ASM-IN-1 shows antiatherosclerotic and anti-inflammatory activity. | ||||||||||||||||||||
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VEGFR2-IN-2 | 99.26% | VEGFR2-IN-2 (compound 6e) is a potent and selective VEGFR2 inhibitor with an IC50 of 19.32 nM. VEGFR2-IN-2 can be used for researching | ||||||||||||||||||||
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3HKT-IN-1 | 3HKT-IN-1 (Compound 17122279) is an Anopheles gambiae 3-hydroxykynurenine transaminase (3HKT) inhibitor. 3HKT-IN-1 can be used for Malaria research. | |||||||||||||||||||||
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AChE-IN-83 | AChE-IN-83 (compound f1) is an inhibitor of AChE that inhibits the growth of nematodes and acetylcholinesterase in rice seeds and is safe for rice seeds. AChE-IN-83 targets Aphelenchoides oryzae with an LC50 value of 19.0 μg/mL (48 hr). AChE-IN-83 can inhibit the population and behavior of rice nematodes in rice seeds, destroy the nematode cuticle, and lead to the production of reactive oxygen species, lipofuscin, and lipids in the nematodes. | |||||||||||||||||||||
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ASM-IN-3 | ASM-IN-3 (Compound 21b) is a selective and BBB-penetrating acid sphingomyelinase (ASM) inhibitor (IC50: 3.37 μM for pure human ASM). ASM-IN-3 improves depression-like behaviors by inhibiting ASM activity and increasing neurogenesis in hippocampus in Reserpine (HY-N0480)-induced depressed rats. | |||||||||||||||||||||
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HV1-IN-2 | 99.31% | HV1-IN-2 (Compound 14c) is a human voltage-gated proton channel (HV1) inhibitor with an IC50 of 2.14 μM. HV1-IN-2 has a potent anticancer activity with significant antiproliferative effects against THP-1 and MCF-7 cells. HV1-IN-2 can be used for cancers research, such as colorectal tumours, leukaemia, and breast cancer. | ||||||||||||||||||||
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HDAC6-IN-80 | HDAC6-IN-80 is an orally active, selective HDAC6 inhibitor with an IC50 of 8.5 nM. HDAC6-IN-80 inhibits lipopolysaccharide-induced microglial activation, reduces the levels of iNOS, COX-2, TNF-α and IL-6, and alleviates sensory hypersensitivity behaviors. HDAC6-IN-80 can be used for the research of inflammatory pain and chemotherapy-induced peripheral neuropathy. | |||||||||||||||||||||
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HDAC4 ligand-2 | 98.83% | HDAC4 ligand-2 is a HDAC4 ligand, which can be used for the synthesis of PROTACs, such as PROTAC HDAC4 Degrader-2 (HY-184524). | ||||||||||||||||||||
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1,4-Bis(pyridin-4-ylmethoxy)benzene | 1,4-Bis(pyridin-4-ylmethoxy)benzene is a metal-organic framework (MOF). | |||||||||||||||||||||
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4-((4-Carboxybenzyl)oxy)benzoic acid | 4-((4-Carboxybenzyl)oxy)benzoic acid (4-[(4-Carboxyphenoxy)methyl]-benzoic acid) is a metal-organic framework (MOF). | |||||||||||||||||||||
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4,4'-(1,2,4,5-Tetrazine-3,6-diyl)dibenzoic acid | 95.0% | 4,4'-(1,2,4,5-Tetrazine-3,6-diyl)dibenzoic acid (4,4-(1,2,4,5-Tetrazine-3,6-diyl)dibenzoic acid) is a metal-organic framework (MOF). | ||||||||||||||||||||
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