2914873-59-7
Chemical Structure
JAK3-IN-18
- CAS No.: 2914873-59-7
- Formula:C18H16FN5O
- Molecular Weight:337.35
IUPAC Name: (R)-1-(4-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-7-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)prop-2-en-1-one
InChIKey: IEQIOPKXNXCQQA-HNNXBMFYSA-N
SMILES: O=C(C=C)N1CC2=C([C@@H](NC3=C4C=CNC4=NC=N3)C1)C=CC(F)=C2
Biological Activity: JAK3-IN-18 is an orally active JAK3 and TEC inhibitor, with IC50s of 0.5391 nM and 12.40 nM, respectively. JAK3-IN-18 demonstrates outstanding selectivity over AK1, AK2, and TYk2, with selectivity ratios exceeding 10,000-fold. JAK3-IN-18 demonstrates excellent therapeutic efficacy in the experimental autoimmune encephalomyelitis (EAE) mouse model. JAK3-IN-18 can be used for the study of multiple sclerosis[1].
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JAK3-IN-18 | JAK3-IN-18 is an orally active JAK3 and TEC inhibitor, with IC50s of 0.5391 nM and 12.40 nM, respectively. JAK3-IN-18 demonstrates outstanding selectivity over AK1, AK2, and TYk2, with selectivity ratios exceeding 10,000-fold. JAK3-IN-18 demonstrates excellent therapeutic efficacy in the experimental autoimmune encephalomyelitis (EAE) mouse model. JAK3-IN-18 can be used for the study of multiple sclerosis. | |||||||||||||||||||||
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Keywords
