2920729-91-3
Chemical Structure
TLR7/8/9 antagonist 2
- CAS No.: 2920729-91-3
- Formula:C23H31N7
- Molecular Weight:405.54
IUPAC Name: 1,6-dimethyl-4-(4-(3-methyl-5-(piperazin-1-yl)pyridin-2-yl)piperidin-1-yl)-1H-pyrazolo[3,4-b]pyridine
InChIKey: RNROUDULHISHKP-UHFFFAOYSA-N
SMILES: CN1N=CC2=C(C=C(C)N=C21)N(CC3)CCC3C4=NC=C(N5CCNCC5)C=C4C
Biological Activity: TLR7/8/9 antagonist 2 is an orally active TLR7/8/9 antagonist. TLR7/8/9 antagonist 2 has inhibitory activities for HEK/hTLR7, HEK/hTLR8 and HEK/hTLR9 with IC50 values of 0.011 μM, 0.029 μM and 0,052 μM, respectively.TLR7/8/9 antagonist 2 has high bioavailability in vivo.TLR7/8/9 antagonist 2 can be used for the research of auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TLR7/8/9 antagonist 2 | 98.96% | TLR7/8/9 antagonist 2 is an orally active TLR7/8/9 antagonist. TLR7/8/9 antagonist 2 has inhibitory activities for HEK/hTLR7, HEK/hTLR8 and HEK/hTLR9 with IC50 values of 0.011 μM, 0.029 μM and 0,052 μM, respectively.TLR7/8/9 antagonist 2 has high bioavailability in vivo.TLR7/8/9 antagonist 2 can be used for the research of auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis. | ||||||||||||||||||||
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Keywords
