2944101-99-7
2944101-99-7
Chemical Structure
PARP1/c-Met-IN-1
- CAS No.: 2944101-99-7
- Formula:C40H33FN8O4
- Molecular Weight:708.74
InChIKey: QJKRRPUDVWORKT-UHFFFAOYSA-N
SMILES: O=C1C=CC(C2=CC=CN=C2)=NN1CCOC3=C4C(C=C(C=C4)N5CCN(CC5)C(C6=C(C=CC(CC7=NNC(C8=C7C=CC=C8)=O)=C6)F)=O)=NC=C3
Biological Activity: PARP1/c-Met-IN-1 (Compound 16) is a selective dual inhibitor for PARP1 and c-Met, with IC50s of 3.3 and 32.2 nM, respectively. PARP1/c-Met-IN-1 induces cell apoptosis and cell cycle arrest in G2/M phase in MDA-MB-231 cells. PARP1/c-Met-IN-1 exhibits antitumor activity in mice[1].
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PARP1/c-Met-IN-1 | PARP1/c-Met-IN-1 (Compound 16) is a selective dual inhibitor for PARP1 and c-Met, with IC50s of 3.3 and 32.2 nM, respectively. PARP1/c-Met-IN-1 induces cell apoptosis and cell cycle arrest in G2/M phase in MDA-MB-231 cells. PARP1/c-Met-IN-1 exhibits antitumor activity in mice. | |||||||||||||||||||||
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Keywords
