2962087-36-9
2962087-36-9
Chemical Structure
TNG456
- CAS No.: 2962087-36-9
- Formula:C18H17F3N6O2
- Molecular Weight:406.36
InChIKey: OINIYYUSEMFTHV-SECBINFHSA-N
SMILES: CN([C@@H](C1=CC=C(C=C1)C(F)(F)F)C)C(C(NC2=C3NN=CC3=C(N=C2)N)=O)=O
Biological Activity: TNG456 is an orally active, CNS-penetrant, selective, MTA-cooperative PRMT5 inhibitor. TNG456 drives dose-dependent antitumor activity in mouse xenograft models. TNG456 can be used for the research of MTAP-null solid tumors, including gliomas, and CNS metastases[1][2].
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TNG456 | TNG456 is an orally active, CNS-penetrant, selective, MTA-cooperative PRMT5 inhibitor. TNG456 drives dose-dependent antitumor activity in mouse xenograft models. TNG456 can be used for the research of MTAP-null solid tumors, including gliomas, and CNS metastases. | |||||||||||||||||||||
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References
- [1]. Kimberly J. Briggs, et al. Abstract 462: TNG456 is a next-generation, brain-penetrant, MTA-cooperative PRMT5 inhibitor for the treatment of solid tumors with MTAP loss. Cancer Res (2025) 85 (8_Supplement_1): 462.
- [2]. Cottrell KM, et al. The Discovery of TNG456: A Highly Potent, Selective, Brain-Penetrant MTA-Cooperative PRMT5 Inhibitor for the Treatment of MTAP-Deleted Cancers. J Med Chem. Published online May 18, 2026. [Content Brief]
Keywords
