2967648-29-7
Chemical Structure
UNC9750
- CAS No.: 2967648-29-7
- Formula:C23H24N6O
- Molecular Weight:400.48
IUPAC Name: 3-(3-(1-cyclobutylpiperidin-4-yl)phenyl)-5-(1H-tetrazol-5-yl)benzo[c]isoxazole
InChIKey: JZWSGCNSEOEUCD-UHFFFAOYSA-N
SMILES: C1(C2=NN=NN2)=CC3=C(ON=C3C=C1)C4=CC(C5CCN(CC5)C6CCC6)=CC=C4
Biological Activity: UNC9750 is an inositol phosphate multikinase (IPMK) inhibitor with IC50 values of 31.6 and 374 nM for IPMK and IP6K2, respectively.. UNC9750 inhibits cellular accumulation of InsP5, the direct product of IPMK kinase activity, while having no effect on either InsP6 or InsP7 levels. UNC9750 has ≥ 75% inhibition of four kinases (DAPK1, DYRK1B, PDGFR, and KDR). UNC9750 can be used for the study of glioblastoma[1].
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UNC9750 | UNC9750 is an inositol phosphate multikinase (IPMK) inhibitor with IC50 values of 31.6 and 374 nM for IPMK and IP6K2, respectively.. UNC9750 inhibits cellular accumulation of InsP5, the direct product of IPMK kinase activity, while having no effect on either InsP6 or InsP7 levels. UNC9750 has ≥ 75% inhibition of four kinases (DAPK1, DYRK1B, PDGFR, and KDR). UNC9750 can be used for the study of glioblastoma. | |||||||||||||||||||||
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Keywords
