2978613-03-3
Chemical Structure
hAChE-IN-7
- CAS No.: 2978613-03-3
- Formula:C38H55N3O3
- Molecular Weight:601.86
InChIKey: ITTFLWMNRNDSBH-UHFFFAOYSA-N
SMILES: COC1=C(C=CC(CNC(CCCCCCC(C)C)=O)=C1)OCCCCCCCNC2=C3C=CC=CC3=NC4=C2CCCC4
Biological Activity: hAChE-IN-7 (compound 5s) is a mixed inhibitor affecting both the catalytic active site (CAS) and peripheral anionic site (PAS) of hAChE. hAChE-IN-7 displays the balanced inhibitory effect on hAChE (IC50=69.8 nM) and hBuChE (IC50=68.0 nM), and exhibits inhibitory activity against β-secretase-1 (BACE-1) (IC50=3.6 μM). hAChE-IN-7 has the potential for Alzheimer's disease (AD) research[1].
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hAChE-IN-7 | hAChE-IN-7 (compound 5s) is a mixed inhibitor affecting both the catalytic active site (CAS) and peripheral anionic site (PAS) of hAChE. hAChE-IN-7 displays the balanced inhibitory effect on hAChE (IC50=69.8 nM) and hBuChE (IC50=68.0 nM), and exhibits inhibitory activity against β-secretase-1 (BACE-1) (IC50=3.6 μM). hAChE-IN-7 has the potential for Alzheimer's disease (AD) research. | |||||||||||||||||||||
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Keywords
