2980502-40-5
2980502-40-5
Chemical Structure
TR-213
- CAS No.: 2980502-40-5
- Formula:C22H20N4O3
- Molecular Weight:388.42
InChIKey: WIYMIFALRIZCFV-UHFFFAOYSA-N
SMILES: N#CC1=CC=CC(C2=CCN(CC2)C3=NC(C4=CC(OC)=C(C=C4N3)OC)=O)=C1
Biological Activity: TR-213 is a potent molecular glue degrader that targets Cyclin K (CDK). TR-213 induces 91% and 56% decrease in CDK12 and Cyclin at 1 μM. TR-213 can inhibit RNA polymerase II activity and regulates alternative polyadenylation (APA) activity. TR-213 can be used for the research of cancer[1].
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TR-213 | TR-213 is a potent molecular glue degrader that targets Cyclin K (CDK). TR-213 induces 91% and 56% decrease in CDK12 and Cyclin at 1 μM. TR-213 can inhibit RNA polymerase II activity and regulates alternative polyadenylation (APA) activity. TR-213 can be used for the research of cancer. | |||||||||||||||||||||
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References
Keywords
