2994637-53-3
Chemical Structure
NLRP3/URAT1-IN-1
- CAS No.: 2994637-53-3
- Formula:C24H17BrN2O3S2
- Molecular Weight:525.44
IUPAC Name: 1-((4-bromonaphthalen-1-yl)methyl)-N-(thiophen-2-ylsulfonyl)-1H-indole-2-carboxamide
InChIKey: QCLJFVGVTBUVEE-UHFFFAOYSA-N
SMILES: O=C(C(N1CC2=C3C=CC=CC3=C(Br)C=C2)=CC4=C1C=CC=C4)NS(=O)(C5=CC=CS5)=O
Biological Activity: NLRP3/URAT1-IN-1 is an orally active double inhibitor of NLRP3 and URAT1 (IC50 = 3.81 μM). NLRP3/URAT1-IN-1 inhibits IL-1β release in LPS (HY-D1056) and ATP-stimulated mouse bone marrow-derived macrophages (BMDMs), with an IC50 of 2.61 μM. NLRP3/URAT1-IN-1 reduces serum uric acid (SUA) and alleviates liver/kidney damage in mice with acute hyperuricemia (HUA). NLRP3/URAT1-IN-1can be used for the study of gout and hyperuricemia[1].
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NLRP3/URAT1-IN-1 | NLRP3/URAT1-IN-1 is an orally active double inhibitor of NLRP3 and URAT1 (IC50 = 3.81 μM). NLRP3/URAT1-IN-1 inhibits IL-1β release in LPS (HY-D1056) and ATP-stimulated mouse bone marrow-derived macrophages (BMDMs), with an IC50 of 2.61 μM. NLRP3/URAT1-IN-1 reduces serum uric acid (SUA) and alleviates liver/kidney damage in mice with acute hyperuricemia (HUA). NLRP3/URAT1-IN-1can be used for the study of gout and hyperuricemia. | |||||||||||||||||||||
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Keywords
