299900-83-7
Chemical Structure
YM-202074
- CAS No.: 299900-83-7
- Formula:C22H30N4O2S
- Molecular Weight:414.56
IUPAC Name: N-cyclohexyl-6-(((2-methoxyethyl)(methyl)amino)methyl)-N-methylbenzo[4,5]imidazo[2,1-b]thiazole-2-carboxamide
InChIKey: AQINBUDFKZIGCN-UHFFFAOYSA-N
SMILES: O=C(N(C1CCCCC1)C)C2=CN3C4=C(C=CC(CN(CCOC)C)=C4)N=C3S2
Biological Activity: YM-202074 is a selective, allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist with high affinity. YM-202074 binds to the allosteric site of rat mGluR1 with a Ki of 4.8 nM. YM-202074 fumarate also inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells with an IC50 of 8.6 nM. YM-202074 has potent neuroprotective effects in transient MCA (tMCA) occlusion rat models[1].
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YM-202074 | YM-202074 is a selective, allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist with high affinity. YM-202074 binds to the allosteric site of rat mGluR1 with a Ki of 4.8 nM. YM-202074 fumarate also inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells with an IC50 of 8.6 nM. YM-202074 has potent neuroprotective effects in transient MCA (tMCA) occlusion rat models. | |||||||||||||||||||||
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Keywords
