2999646-13-6
2999646-13-6
Chemical Structure
Sirt1/2-IN-4
- CAS No.: 2999646-13-6
- Formula:C21H20N4O3S2
- Molecular Weight:440.54
InChIKey: CNBCIGYQUBSQAF-UHFFFAOYSA-N
SMILES: O=S(NC1=CC(SC2=NNC=N2)=C(C3=C1C=CC=C3)O)(C4=C(C)C(C)=C(C)C=C4)=O
Biological Activity: Sirt1/2-IN-4 (compound PS3) is a triple inhibitor of SIRT1/2/3 with IC50s of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (SIRT3), respsectivley. Sirt1/2-IN-4 completely blocks p53 deacetylation, with potential anti-cancer activity[1].
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Sirt1/2-IN-4 | Sirt1/2-IN-4 (compound PS3) is a triple inhibitor of SIRT1/2/3 with IC50s of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (SIRT3), respsectivley. Sirt1/2-IN-4 completely blocks p53 deacetylation, with potential anti-cancer activity. | |||||||||||||||||||||
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