2. Cell Cycle/DNA Damage Apoptosis Epigenetics
  3. Sirtuin Apoptosis
  4. Sirt1/2-IN-4

Sirt1/2-IN-4 (compound PS3) is a triple inhibitor of SIRT1/2/3 with IC50s of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (SIRT3), respsectivley. Sirt1/2-IN-4 completely blocks p53 deacetylation, with potential anti-cancer activity.

For research use only. We do not sell to patients.

Sirt1/2-IN-4 Chemical Structure

Sirt1/2-IN-4 Chemical Structure

CAS No. : 2999646-13-6

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Sirt1/2-IN-4 Related Antibodies

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Description

Sirt1/2-IN-4 (compound PS3) is a triple inhibitor of SIRT1/2/3 with IC50s of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (SIRT3), respsectivley. Sirt1/2-IN-4 completely blocks p53 deacetylation, with potential anti-cancer activity[1].

IC50 & Target

IC50: 1.2 μM (SIRT1), 1.9 μM (SIRT2), 18.6 μM (SIRT3)[1]
In Vitro

Sirt1/2-IN-4 (compound PS3) (5 μM; 48 h) induces apoptosis in different tumor cells, with IC50s of 6.5 μM (MV4-11), 9.2μM (MOLM-13), 27.2 μM (THP1), 17.4 μM (Jurkat), respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sirt1/2-IN-4 Related Antibodies
Molecular Weight

440.54

Formula

C21H20N4O3S2
CAS No.
SMILES

O=S(NC1=CC(SC2=NNC=N2)=C(C3=C1C=CC=C3)O)(C4=C(C)C(C)=C(C)C=C4)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Sirt1/2-IN-4 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sirt1/2-IN-42999646-13-6SirtuinApoptosisInhibitorinhibitorinhibit

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