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Cat. No.: HY-155729

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Sirt1/2-IN-4

Sirt1/2-IN-4 (compound PS3) is a triple inhibitor of SIRT1/2/3 with IC₅₀s of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (SIRT3), respsectivley. Sirt1/2-IN-4 completely blocks p53 deacetylation, with potential anti-cancer activity.

For research use only. We do not sell to patients.

CAS No.: 2999646-13-6
Formula: C₂₁H₂₀N₄O₃S₂
Molecular Weight:440.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Sirt1/2-IN-4 Chemical Structure

CAS No.: 2999646-13-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 1.2 μM (SIRT1), 1.9 μM (SIRT2), 18.6 μM (SIRT3)^[1]

All Sirtuin Isoforms :

In Vitro

Sirt1/2-IN-4 (compound PS3) (5 μM; 48 h) induces apoptosis in different tumor cells, with IC₅₀s of 6.5 μM (MV4-11), 9.2μM (MOLM-13), 27.2 μM (THP1), 17.4 μM (Jurkat), respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2999646-13-6
Molecular Weight 440.54
Formula C₂₁H₂₀N₄O₃S₂
SMILES

O=S(NC1=CC(SC2=NNC=N2)=C(C3=C1C=CC=C3)O)(C4=C(C)C(C)=C(C)C=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cai H, et al. Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia Cells. J Chem Inf Model. 2023 Aug 14;63(15):4780-4790. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Sirt1/2-IN-4

All Sirtuin Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Sirt1/2-IN-4 Related Classifications

HY-155729 Related Classifications