3018962-69-8
3018962-69-8
Chemical Structure
KGP591
- CAS No.: 3018962-69-8
- Formula:C24H21NO5
- Molecular Weight:403.43
InChIKey: JQHIEFZGSRAUDF-UHFFFAOYSA-N
SMILES: COC1=CC(C(C2=CNC3=CC(C4=CC=CC(O)=C4)=CC=C23)=O)=CC(OC)=C1OC
Biological Activity: KGP591 is a tubulin polymerization inhibitor (IC50 0.57 µM). KGP591 induces significant G2/M stagnation, inhibits cell migration, disrupts microtubule structure and cell morphology in MDA-MB-231 cells. KGP591 shows antitumor activity in orthotopic model of kidney cancer (RENCA)[1].
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KGP591 | KGP591 is a tubulin polymerization inhibitor (IC50 0.57 µM). KGP591 induces significant G2/M stagnation, inhibits cell migration, disrupts microtubule structure and cell morphology in MDA-MB-231 cells. KGP591 shows antitumor activity in orthotopic model of kidney cancer (RENCA). | |||||||||||||||||||||
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