3028123-48-7
Chemical Structure
HJ03
- CAS No.: 3028123-48-7
- Formula:C16H22Cl3N7O4
- Molecular Weight:482.75
InChIKey: VHDIXRJWOZSBHF-UHFFFAOYSA-N
SMILES: ClCCNC(N(CCN(C1=CC=CC(Cl)=C1)CCN(C(NCCCl)=O)N=O)N=O)=O
Biological Activity: HJ03 is a blood-brain barrier-permeable, orally active DNA damage and ferroptosis inducer. HJ03 triggers ferroptosis by increasing intracellular ROS, Fe2+ accumulation and lipid peroxidation. HJ03 induces DNA adducts and interstrand crosslinks, blocks DNA replication and transcription, arrests cells at the G2/M phase and induces apoptosis. HJ03 can be used in the research of glioblastoma multiforme and colorectal cancer[1].
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HJ03 | HJ03 is a blood-brain barrier-permeable, orally active DNA damage and ferroptosis inducer. HJ03 triggers ferroptosis by increasing intracellular ROS, Fe2+ accumulation and lipid peroxidation. HJ03 induces DNA adducts and interstrand crosslinks, blocks DNA replication and transcription, arrests cells at the G2/M phase and induces apoptosis. HJ03 can be used in the research of glioblastoma multiforme and colorectal cancer. | |||||||||||||||||||||
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Keywords
