3028442-70-5
3028442-70-5
Chemical Structure
HDAC6-IN-65
- CAS No.: 3028442-70-5
- Formula:C20H18ClN3O4S
- Molecular Weight:431.89
InChIKey: OWFIIYCSCPRQDG-UHFFFAOYSA-N
SMILES: O=S(N(CC1=CN=CC=C1)CC2=CC=C(C=C2)C(NO)=O)(C3=C(C=CC=C3)Cl)=O
Biological Activity: HDAC6-IN-65 is a selective HDAC6 inhibitor (IC50 = 0.9 nM) and also exhibits a certain suppressive effect on HDAC3 (IC50 = 39.4 nM). HDAC6-IN-65 can induce the accumulation of α-tubulin (ac-tubulin) and acetylated histone H3 (ac-histone H3, a class I HDAC inhibition marker) in Neuro-2a cells. HDAC6-IN-65 can be used for the study of melanoma[1].
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HDAC6-IN-65 | HDAC6-IN-65 is a selective HDAC6 inhibitor (IC50 = 0.9 nM) and also exhibits a certain suppressive effect on HDAC3 (IC50 = 39.4 nM). HDAC6-IN-65 can induce the accumulation of α-tubulin (ac-tubulin) and acetylated histone H3 (ac-histone H3, a class I HDAC inhibition marker) in Neuro-2a cells. HDAC6-IN-65 can be used for the study of melanoma. | |||||||||||||||||||||
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References
Keywords
