3031606-85-3
3031606-85-3
Chemical Structure
PROTAC KAT2A/B degrader-1
- CAS. Nr.: 3031606-85-3
- Formula:C31H31ClN6O6
- Molecular Weight:619.07
InChIKey: QGPFBQATGYQOBB-KYWQPSMRSA-N
SMILES: CN1C[C@H](NC2=C(Cl)C(N(C)N=C2)=O)C[C@H](C3=CC=C(COC4=CC5=C(C(N(C6C(NC(CC6)=O)=O)C5=O)=O)C=C4)C=C3)C1
Biological Activity: PROTAC KAT2A/B degrader-1 is an orally active CRBN-baed histone acetyltransferase KAT2A/KAT2B PROTAC degrader. PROTAC KAT2A/B degrader-1 induces degradation of KAT2A and KAT2B proteins. PROTAC KAT2A/B degrader-1 inhibits proliferation of acute myeloid leukemia and small cell lung cancer cells. PROTAC KAT2A/B degrader-1 can be used for the research of acute myeloid leukemia, small cell lung cance[1].
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PROTAC KAT2A/B degrader-1 | PROTAC KAT2A/B degrader-1 is an orally active CRBN-baed histone acetyltransferase KAT2A/KAT2B PROTAC degrader. PROTAC KAT2A/B degrader-1 induces degradation of KAT2A and KAT2B proteins. PROTAC KAT2A/B degrader-1 inhibits proliferation of acute myeloid leukemia and small cell lung cancer cells. PROTAC KAT2A/B degrader-1 can be used for the research of acute myeloid leukemia, small cell lung cance. | |||||||||||||||||||||
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