3032075-32-1
Chemical Structure
IRAK4-IN-19
- CAS 番号: 3032075-32-1
- Formula:C25H26F2N8O
- Molecular Weight:492.52
IUPAC Name: (1S,2S,3R,4R)-3-((5-(difluoromethyl)-2-((1-isopropyl-1H-indazol-6-yl)amino)-5H-pyrrolo[3,2-d]pyrimidin-4-yl)amino)bicyclo[2.2.1]hept-5-ene-2-carboxamide
InChIKey: SCFUOBOKAOMGPA-BBNYVJOESA-N
SMILES: CC(N1N=CC2=C1C=C(NC(N=C3C=C4)=NC(N[C@H]5[C@@H](C(N)=O)[C@@H]6C=C[C@H]5C6)=C3N4C(F)F)C=C2)C
Biological Activity: IRAK4-IN-19 is a potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC50 value of 4.3 nM. IRAK4-IN-19 can inhibit LPS-induced IL23 production in THP and DC cells, and stop arthritis development in arthritis rats. IRAK4-IN-19 can be used for researching arthritis disease[1].
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IRAK4-IN-19 | IRAK4-IN-19 is a potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC50 value of 4.3 nM. IRAK4-IN-19 can inhibit LPS-induced IL23 production in THP and DC cells, and stop arthritis development in arthritis rats. IRAK4-IN-19 can be used for researching arthritis disease. | |||||||||||||||||||||
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Keywords
