3032444-06-4
Chemical Structure
CZL-077
- CAS No.: 3032444-06-4
- Formula:C30H26F3N5O2S
- Molecular Weight:577.62
InChIKey: SWOQLRULNPDIHL-GSPPDTAYSA-N
SMILES: CC1=NC(CC2)=C(S1)C[C@@H]2N3C([C@H]4N(C5=CC=C(F)C(F)=C5)C([C@@H](F)C4)=O)=NC6=CC(C7=C(C)ON=C7C)=CC=C63
Biological Activity: CZL-077 is a potent, selective, and orally active p300/CBP bromodomain (BRD) inhibitor (p300 IC50 = 0.034 μM, CBP IC50 = 0.052 μM) exhibiting high selectivity over the BRDs of BET proteins (BRD2/3/4). CZL-077 inhibits cell growth with IC50 values of 0.024 μM and 5.6 μM in OPM-2 and 22RV1 cells, respectively. CZL-077 shows antitumor efficacy in OPM-2 and 22RV1 xenograft mouse models. CZL-077 can be used for multiple myeloma and prostate cancer research[1].
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CZL-077 | CZL-077 is a potent, selective, and orally active p300/CBP bromodomain (BRD) inhibitor (p300 IC50 = 0.034 μM, CBP IC50 = 0.052 μM) exhibiting high selectivity over the BRDs of BET proteins (BRD2/3/4). CZL-077 inhibits cell growth with IC50 values of 0.024 μM and 5.6 μM in OPM-2 and 22RV1 cells, respectively. CZL-077 shows antitumor efficacy in OPM-2 and 22RV1 xenograft mouse models. CZL-077 can be used for multiple myeloma and prostate cancer research. | |||||||||||||||||||||
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