3033258-60-2
Chemical Structure
NF-κB-IN-4
- CAS No.: 3033258-60-2
- Formula:C18H15FN4O
- Molecular Weight:322.34
IUPAC Name: (3aS,10aS)-10-hydroxy-4-(2-(6-methylpyridin-2-yl)-2-oxoethyl)-9-(5,6,7,8-tetrahydronaphthalene-1-carboxamido)hexahydro-1H,8H-dipyrrolo[1,2-c:3',2'-d]pyrimidine-2,6-diiminium
InChIKey: FXSXXEDKCSJAQA-UHFFFAOYSA-N
SMILES: COC1=CC(C2=C3CCC4=C(C3=NC(N)=N2)C=C(C=C4)F)=CN=C1
Biological Activity: NF-κB-IN-4 (compound 17) is a potent NF-κB pathway inhibitor with blood brain barrier (BBB) permeability. NF-κB-IN-4 exhibits potential anti-neuroinflammatory activity with low toxicity. NF-κB-IN-4 can block the activation and phosphorylation of IκBα, reduce expression of NLRP3, and thus inhibit NF-κB activation. NF-κB-IN-4 can be used for neuroinflammation related diseases research[1].
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NF-κB-IN-4 | 98.51% | NF-κB-IN-4 (compound 17) is a potent NF-κB pathway inhibitor with blood brain barrier (BBB) permeability. NF-κB-IN-4 exhibits potential anti-neuroinflammatory activity with low toxicity. NF-κB-IN-4 can block the activation and phosphorylation of IκBα, reduce expression of NLRP3, and thus inhibit NF-κB activation. NF-κB-IN-4 can be used for neuroinflammation related diseases research. | ||||||||||||||||||||
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