3034959-68-4
Chemical Structure
EPIC-0628
- CAS No.: 3034959-68-4
- Formula:C20H17F4N3O
- Molecular Weight:391.36
InChIKey: LMXOJEUTETZQDO-UHFFFAOYSA-N
SMILES: FC(F)(F)C(C1=C2CNCC1)=NN2CC3=CC=CC(OC4=CC=C(F)C=C4)=C3
Biological Activity: EPIC-0628 is an inhibitor of the HOTAIR-EZH2 interaction and promotes ATF3 expression. The long noncoding RNA HOTAIR has been found to regulate glioblastoma (GBM) progression and mediate DNA damage repair (DDR) by interacting with the catalytic subunit EZH2 of PRC2. EPIC-0628 also inhibits the ATF3-p38-E2F1 DDR pathway to inhibit the HR pathway and upregulates CDKN1A (p21) expression, causing cell cycle arrest. EPIC-0628 also synergizes with Temozolomide (TMZ) (HY-17364) to enhance its in vivo potency[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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EPIC-0628 | 98.66% | EPIC-0628 is an inhibitor of the HOTAIR-EZH2 interaction and promotes ATF3 expression. The long noncoding RNA HOTAIR has been found to regulate glioblastoma (GBM) progression and mediate DNA damage repair (DDR) by interacting with the catalytic subunit EZH2 of PRC2. EPIC-0628 also inhibits the ATF3-p38-E2F1 DDR pathway to inhibit the HR pathway and upregulates CDKN1A (p21) expression, causing cell cycle arrest. EPIC-0628 also synergizes with Temozolomide (TMZ) (HY-17364) to enhance its in vivo potency. | ||||||||||||||||||||
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-
Similarity Score 0.49
HY-19889AJNJ-18038683 free base -
Similarity Score 0.48
HY-10629RLXR-623 (Standard) -
Similarity Score 0.47
HY-163368HDAC6-IN-34 -
Similarity Score 0.46
HY-147705PPARγ phosphorylation inhibitor 1 -
Similarity Score 0.46
HY-179559OPN-9643 -
Similarity Score 0.46
HY-100017RBAY-876 (Standard) -
Similarity Score 0.46
HY-179505OPN-9652 -
Similarity Score 0.45
HY-12507GSK-7975A -
Similarity Score 0.45
HY-147005piCRAC-1 -
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