3035577-19-3
Chemical Structure
JN122
- CAS No.: 3035577-19-3
- Formula:C33H37Cl2N3O4
- Molecular Weight:610.57
InChIKey: AJQDQXYTMUFRRF-MKYOLNSUSA-N
SMILES: CCN1[C@H]([C@@H]([C@@]2([C@@H]1CC(C)(C)C)CNC3=CC(Cl)=CC=C32)C4=CC(Cl)=CC=C4)C(NC5=CC=C(C=C5OC)C(O)=O)=O
Biological Activity: JN122, a spiroindoline-containing molecule, is a MDM2 inhibitor. JN122 Inhibits MDM2/p53 protein–protein interaction and exerts robust in vivo antitumor efficacy. JN122 has antiproliferative activity in HCT-116 cells and HEK-293 cells with IC50 values of 39.6 nM and 4.28μM, respectively. JN122 can promote activation of p53 and its target genes, inhibited cell cycle progression, and induced cell apoptosis[1].
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JN122 | JN122, a spiroindoline-containing molecule, is a MDM2 inhibitor. JN122 Inhibits MDM2/p53 protein–protein interaction and exerts robust in vivo antitumor efficacy. JN122 has antiproliferative activity in HCT-116 cells and HEK-293 cells with IC50 values of 39.6 nM and 4.28μM, respectively. JN122 can promote activation of p53 and its target genes, inhibited cell cycle progression, and induced cell apoptosis. | |||||||||||||||||||||
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Keywords
