3054791-71-5
3054791-71-5
Chemical Structure
SHR5428
- CAS No.: 3054791-71-5
- Formula:C22H23F3N5O2P
- Molecular Weight:477.42
InChIKey: ADMNNQNUFZLRNL-KBPBESRZSA-N
SMILES: CP(C1=C(C=CC2=C1NC=C2C3=C(C=NC(N[C@@H]4C[C@H](CCC4)O)=N3)C(F)(F)F)C#N)(C)=O
Biological Activity: SHR5428 is a potent, orally active, selective and noncovalent inhibitor of CDK7 with highly potent CDK7 enzymatic activity (IC50=2.3 nM). SHR5428 inhibits triple negative breast cancer cellular activity on MDA-MB-468 cell (IC50=6.6 nM)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SHR5428 | 99.80% | SHR5428 is a potent, orally active, selective and noncovalent inhibitor of CDK7 with highly potent CDK7 enzymatic activity (IC50=2.3 nM). SHR5428 inhibits triple negative breast cancer cellular activity on MDA-MB-468 cell (IC50=6.6 nM). | ||||||||||||||||||||
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References
Keywords
