3055112-52-9
Chemical Structure
Xanthine oxidase-IN-23
- CAS No.: 3055112-52-9
- Formula:C17H12Br2O5
- Molecular Weight:456.08
InChIKey: GAOZKDRDYCECLR-ZPUQHVIOSA-N
SMILES: O=C(/C=C/C1=CC(O)=C(O)C=C1Br)/C=C/C2=CC(O)=C(O)C=C2Br
Biological Activity: Xanthine oxidase-IN-23 (Compound BPF) is an orally active, reversible, mixed-type Xanthine oxidase inhibitor with an IC50 of 3.33 μM. Xanthine oxidase-IN-23 directly binds to XOD in a reversible mixed-type manner to inhibit its catalytic activity. Xanthine oxidase-IN-23 upregulates ABCG2 and downregulates GLUT9 to promote renal urate excretion. Xanthine oxidase-IN-23 reduces serum urate levels and improves renal function in hyperuricemic mice. Xanthine oxidase-IN-23 can be used in the research of hyperuricemia[1].
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Xanthine oxidase-IN-23 | Xanthine oxidase-IN-23 (Compound BPF) is an orally active, reversible, mixed-type Xanthine oxidase inhibitor with an IC50 of 3.33 μM. Xanthine oxidase-IN-23 directly binds to XOD in a reversible mixed-type manner to inhibit its catalytic activity. Xanthine oxidase-IN-23 upregulates ABCG2 and downregulates GLUT9 to promote renal urate excretion. Xanthine oxidase-IN-23 reduces serum urate levels and improves renal function in hyperuricemic mice. Xanthine oxidase-IN-23 can be used in the research of hyperuricemia. | |||||||||||||||||||||
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