3058652-58-4

WRN-IN-19 Chemical Structure
3058652-58-4

Chemical Structure

WRN-IN-19

  • CAS No.: 3058652-58-4
  • Formula:C23H26F3N3O3
  • Molecular Weight:449.47

InChIKey: DJHHRIDLXNEARE-SFHVURJKSA-N

SMILES: O=C(N1C[C@@H](C(N2CC3(CCC3)C2)=O)N(C(C=C)=O)CC1)CC4=CC=C(C(F)(F)F)C=C4

Biological Activity: WRN-IN-19 (Compound (S)-27) is a covalent WRN helicase inhibitor, with pIC50 (0 h/4 h) = 5.4/7.5 in the DNA-unwinding 5 endpoint assays. WRN-IN-19 shows synthetic lethality in MSI-H (high microsatellite instability) cancer cells[1].

Cat. No. Product Name Purity Description Pricing
HY-174217 		WRN-IN-19 WRN-IN-19 (Compound (S)-27) is a covalent WRN helicase inhibitor, with pIC50 (0 h/4 h) = 5.4/7.5 in the DNA-unwinding 5 endpoint assays. WRN-IN-19 shows synthetic lethality in MSI-H (high microsatellite instability) cancer cells.
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