3059574-58-9
Chemical Structure
WCF-598
- CAS No.: 3059574-58-9
- Formula:C54H63N5O7
- Molecular Weight:894.11
InChIKey: IMTNUGPKWHDPFP-UHFFFAOYSA-N
SMILES: O=C(CCCCCCCCCCCOC1=CC=CC2=C1CN(C2=O)C3CCC(NC3=O)=O)NC4=CC5=C(N(C6=CC7=C(C=C6C(C8=CC=C(C=C8)C(O)=O)=N5)C(C)(C)CCC7(C)C)C)C=C4
Biological Activity: WCF-598 is a RXRγ (Kd: 234.2 nM) PROTAC degrader. WCF-598 induces RXRγ degradation via the ubiquitin-proteasome pathway and binds directly to RXRγ. WCF-598 indirectly induces AR-V7 degradation, impairs the stability of the RXRγ-AR-V7 complex, downregulates AR-V7 levels, and inhibits the transcription of downstream target genes of AR-V7. WCF-598 induces tumor cell apoptosis, inhibits cell proliferation, activates the p53 signaling pathway, and suppresses cell cycle progression. WCF-598 can be used for the research of prostate cancer[1].
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WCF-598 | WCF-598 is a RXRγ (Kd: 234.2 nM) PROTAC degrader. WCF-598 induces RXRγ degradation via the ubiquitin-proteasome pathway and binds directly to RXRγ. WCF-598 indirectly induces AR-V7 degradation, impairs the stability of the RXRγ-AR-V7 complex, downregulates AR-V7 levels, and inhibits the transcription of downstream target genes of AR-V7. WCF-598 induces tumor cell apoptosis, inhibits cell proliferation, activates the p53 signaling pathway, and suppresses cell cycle progression. WCF-598 can be used for the research of prostate cancer. | |||||||||||||||||||||
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Keywords
