3068162-16-0
Chemical Structure
PROTAC HDAC6 degrader 6
- CAS No.: 3068162-16-0
- Formula:C41H48N8O11
- Molecular Weight:828.87
InChIKey: JFUQCXOUDYXHML-CPHIHMHPSA-N
SMILES: COC(C=C1/N=N/C2=C3C(C(N(C4C(NC(CC4)=O)=O)C3)=O)=CC=C2)=C(C(OC)=C1)OCC(NCCCC(NC5=CC=C(C=C5)C(NCCCCCCC(NO)=O)=O)=O)=O
Biological Activity: PROTAC HDAC6 degrader 6 is a HDAC6 PROTAC degrader that recruits CRBN, and also a photoactivatable photochemical targeting chimeric (PHOTAC). PROTAC HDAC6 degrader 6 switches between cis and trans conformations upon illumination, in which the cis conformation binds HDAC6 and CRBN to form a ternary complex, and induces HDAC6 degradation via ubiquitin-like modification, polyubiquitination and proteasomal pathways. PROTAC HDAC6 degrader 6 can be used in the research of multiple myeloma[1].
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PROTAC HDAC6 degrader 6 | PROTAC HDAC6 degrader 6 is a HDAC6 PROTAC degrader that recruits CRBN, and also a photoactivatable photochemical targeting chimeric (PHOTAC). PROTAC HDAC6 degrader 6 switches between cis and trans conformations upon illumination, in which the cis conformation binds HDAC6 and CRBN to form a ternary complex, and induces HDAC6 degradation via ubiquitin-like modification, polyubiquitination and proteasomal pathways. PROTAC HDAC6 degrader 6 can be used in the research of multiple myeloma. | |||||||||||||||||||||
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