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Cat. No.: HY-174877

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PROTAC HDAC6 degrader 6

PROTAC HDAC6 degrader 6 is a HDAC6 PROTAC degrader that recruits CRBN, and also a photoactivatable photochemical targeting chimeric (PHOTAC). PROTAC HDAC6 degrader 6 switches between cis and trans conformations upon illumination, in which the cis conformation binds HDAC6 and CRBN to form a ternary complex, and induces HDAC6 degradation via ubiquitin-like modification, polyubiquitination and proteasomal pathways. PROTAC HDAC6 degrader 6 can be used in the research of multiple myeloma.
(Pink: Target protein ligand; Blue: Cereblon ligand (HY-A0003); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 3068162-16-0
Formula: C₄₁H₄₈N₈O₁₁
Molecular Weight:828.87

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

PROTAC HDAC6 degrader 6 Chemical Structure

CAS No.: 3068162-16-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

PROTAC HDAC6 degrader 6 is a HDAC6 PROTAC degrader that recruits CRBN, and also a photoactivatable photochemical targeting chimeric (PHOTAC). PROTAC HDAC6 degrader 6 switches between cis and trans conformations upon illumination, in which the cis conformation binds HDAC6 and CRBN to form a ternary complex, and induces HDAC6 degradation via ubiquitin-like modification, polyubiquitination and proteasomal pathways. PROTAC HDAC6 degrader 6 can be used in the research of multiple myeloma^[1]. (Pink: Target protein ligand; Blue: Cereblon ligand (HY-A0003); Black: linker).

IC₅₀ & Target

^[1]

HDAC6

All PROTACs Isoforms :

All HDAC Isoforms :

In Vitro

When activated to the cis conformation by 390 nm light, PROTAC HDAC6 degrader 6 (PHOTAC 12) (1 μM; 6 h) induces approximately 50% HDAC6 degradation in MM.1S cells; in contrast, its trans conformation (protected from light, pre-irradiated with 505 nm light) causes less than 10% HDAC6 degradation^[1].
PROTAC HDAC6 degrader 6 (1 μM; 6 h) selectively degrades HDAC6 but not HDAC1, HDAC3, or HDAC8 in MM.1S cells; its trans conformation does not degrade these off-target HDAC subtypes^[1].
PROTAC HDAC6 degrader 6 (0.123-10 μM; 6 h) achieves maximum degradation of HDAC6 in MM.1S cells at 0.37 μM, and HDAC6 levels remain stable at concentrations up to 10 μM^[1].
Degradation of HDAC6 in MM.1S cells mediated by PROTAC HDAC6 degrader 6 (1 μM; 6 h) depends on HDAC6 binding, CRBN recruitment, neddylation, and proteasomal activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MM.1S cells
Concentration:

1 μM
Incubation Time:

6 h
Result:

Selectively degraded HDAC6 over HDAC1, HDAC3, and HDAC8 in MM.1S cells when activated to its cis-state with 390 nm light, while its trans-state did not degrade these off-target HDAC isoforms.

Western Blot Analysis^[1]

Cell Line:

MM.1S cells
Concentration:

0.123, 0.37, 1.11, 3.33, 10 μM
Incubation Time:

6 h
Result:

Achieved maximum HDAC6 degradation in MM.1S cells at 0.37 μM, with stable HDAC6 levels at concentrations up to 10 μM.

Chemical Information

CAS No. 3068162-16-0
Molecular Weight 828.87
Formula C₄₁H₄₈N₈O₁₁
SMILES

COC(C=C1/N=N/C2=C3C(C(N(C4C(NC(CC4)=O)=O)C3)=O)=CC=C2)=C(C(OC)=C1)OCC(NCCCC(NC5=CC=C(C=C5)C(NCCCCCCC(NO)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wurnig SL, et al. Light-activatable photochemically targeting chimeras (PHOTACs) enable the optical control of targeted protein degradation of HDAC6. RSC medicinal chemistry. 2025 Jun 18;16(6):2452-2459. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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