3075001-08-7
Chemical Structure
PROTAC FLT3/CDKs degrader-1
- CAS No.: 3075001-08-7
- Formula:C40H42N12O5
- Molecular Weight:770.84
InChIKey: GEZDLCVCOOEQEF-UHFFFAOYSA-N
SMILES: O=C(NC1=O)CCC1N(C2=O)C(C3=C2C=CC(N(CC4)CCC4CN(CC5)CCN5CC6=CC=C(NC(C7=NNC=C7NC8=C9C(NC=C9)=NC=N8)=O)C=C6)=C3)=O
Biological Activity: PROTAC FLT3/CDKs degrader-1 (Compound C3) is a degrader for cyclin-dependent kinases (DC50 is 18.73 nM for CDK2) and the FMS-like tyrosine kinase 3 (FLT3). PROTAC FLT3/CDKs degrader-1 induces differentation of HL-60 (72.77% differentation at 6.25 nM), inhibits proliferation of AML cells, with IC50s of 2.9-37 nM. PROTAC FLT3/CDKs degrader-1 is potential for ameliorating acute myeloid leukemia. (Pink: ligand for target protein FLT3/CDKs ligand-1 (HY-161709); Black: linker (HY-W012935); Black: ligand for E3 ligase Thalidomide 5-fluoride (HY-W087383))[1]
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PROTAC FLT3/CDKs degrader-1 | PROTAC FLT3/CDKs degrader-1 (Compound C3) is a degrader for cyclin-dependent kinases (DC50 is 18.73 nM for CDK2) and the FMS-like tyrosine kinase 3 (FLT3). PROTAC FLT3/CDKs degrader-1 induces differentation of HL-60 (72.77% differentation at 6.25 nM), inhibits proliferation of AML cells, with IC50s of 2.9-37 nM. PROTAC FLT3/CDKs degrader-1 is potential for ameliorating acute myeloid leukemia. (Pink: ligand for target protein FLT3/CDKs ligand-1 (HY-161709); Black: linker (HY-W012935); Black: ligand for E3 ligase Thalidomide 5-fluoride (HY-W087383)) | |||||||||||||||||||||
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Keywords
