3076450-41-1
3076450-41-1
Chemical Structure
CDK12/13-IN-2
- CAS No.: 3076450-41-1
- Formula:C24H22FN7O2
- Molecular Weight:459.48
InChIKey: JJNDYWVSOBGLHU-UHFFFAOYSA-N
SMILES: C=CC(NC1=CC=C(C2=NN3C(C=C2)=NC(CC(NC4=NNC(C5CCC5)=C4)=O)=C3)C=C1F)=O
Biological Activity: CDK12/13-IN-2 (Compound 24) is a covalent inhibitor of CDK12/13, with IC50 values of 15.5 nM and 12.2 nM for CDK12 and CDK13, respectively. CDK12/13-IN-2 can inhibit the proliferation of breast cancer cells and can be used in the research of triple-negative breast cancer[1].
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CDK12/13-IN-2 | CDK12/13-IN-2 (Compound 24) is a covalent inhibitor of CDK12/13, with IC50 values of 15.5 nM and 12.2 nM for CDK12 and CDK13, respectively. CDK12/13-IN-2 can inhibit the proliferation of breast cancer cells and can be used in the research of triple-negative breast cancer. | |||||||||||||||||||||
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