3077136-87-6
3077136-87-6
Chemical Structure
XH-30
- CAS No.: 3077136-87-6
- Formula:C19H19N3O3
- Molecular Weight:337.37
InChIKey: LMJMLNIWVIOFRW-UHFFFAOYSA-N
SMILES: NC1=C(C=C2N=C(OC2=C1C3=C(C(O)=CC=C3C)C)C4CC4)C(N)=O
Biological Activity: XH-30 is a potent, selective, and orally active PKMYT1 inhibitor, with an IC50 of 4.1 nM. XH-30 suppresses the proliferation of P53-mutated triple-negative breast cancer (TNBC) cells by inducing G2/M phase release, DNA damage, and apoptosis. XH-30 demonstrates antitumor effects in an MDA-MB-231 mouse model. XH-30 can be used for P53-mutated TNBC research[1].
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XH-30 | XH-30 is a potent, selective, and orally active PKMYT1 inhibitor, with an IC50 of 4.1 nM. XH-30 suppresses the proliferation of P53-mutated triple-negative breast cancer (TNBC) cells by inducing G2/M phase release, DNA damage, and apoptosis. XH-30 demonstrates antitumor effects in an MDA-MB-231 mouse model. XH-30 can be used for P53-mutated TNBC research. | |||||||||||||||||||||
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References
Keywords
