3083494-45-2
3083494-45-2
Chemical Structure
AAK1-IN-10
- CAS No.: 3083494-45-2
- Formula:C19H23F4N3O3
- Molecular Weight:417.40
SMILES: FC(F)C1=NC=CC(C2=CC=C(OC[C@](N)(C)C[C@](O)(C)CO)C(C(F)F)=N2)=C1
Biological Activity: AAK1-IN-10 (Compound 1-2) is an AAK1 inhibitor. AAK1-IN-10 has significant AAK1 enzyme inhibitory activity (IC50: 9.62 nM). AAK1-IN-10 mainly exerts its effects by inhibiting the activity of connexin-associated kinase 1 (AAK1). AAK1-IN-10 has low cardiotoxicity (IC50 = 13.7 μM). AAK1-IN-10 can be used in the study of diabetic neuropathy and postherpetic pain[1].
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AAK1-IN-10 | AAK1-IN-10 (Compound 1-2) is an AAK1 inhibitor. AAK1-IN-10 has significant AAK1 enzyme inhibitory activity (IC50: 9.62 nM). AAK1-IN-10 mainly exerts its effects by inhibiting the activity of connexin-associated kinase 1 (AAK1). AAK1-IN-10 has low cardiotoxicity (IC50 = 13.7 μM). AAK1-IN-10 can be used in the study of diabetic neuropathy and postherpetic pain. | |||||||||||||||||||||
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