3084810-86-3
Chemical Structure
PARP1/NAMPT-IN-1
- CAS No.: 3084810-86-3
- Formula:C35H31FN6O3
- Molecular Weight:602.66
InChIKey: MJYITQPUTGMUNU-UHFFFAOYSA-N
SMILES: O=C1C2=CC=CC=C2C(CC3=CC(C(N4CCC(CC4)C5=CC=C(C=C5)NC(N6CC7=C(C6)C=NC=C7)=O)=O)=C(C=C3)F)=NN1
Biological Activity: PARP1/NAMPT-IN-1 is a potent and dual PARP1 and NAMPT inhibitor with IC50 values of 1.2 nM and 6.7 nM, respectively. PARP1/NAMPT-IN-1 can disrupt the homologous recombination repair (HRR) pathway, leading to the accumulation of DNA double-strand breaks (DSBs), inducing cell cycle arrest and apoptosis, and also has antimigratory effects. PARP1/NAMPT-IN-1 exhibits excellent antitumor effects in a breast cancer xenograft model. PARP1/NAMPT-IN-1 can be used for the study of triple-negative breast cancer (TNBC)[1].
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PARP1/NAMPT-IN-1 | PARP1/NAMPT-IN-1 is a potent and dual PARP1 and NAMPT inhibitor with IC50 values of 1.2 nM and 6.7 nM, respectively. PARP1/NAMPT-IN-1 can disrupt the homologous recombination repair (HRR) pathway, leading to the accumulation of DNA double-strand breaks (DSBs), inducing cell cycle arrest and apoptosis, and also has antimigratory effects. PARP1/NAMPT-IN-1 exhibits excellent antitumor effects in a breast cancer xenograft model. PARP1/NAMPT-IN-1 can be used for the study of triple-negative breast cancer (TNBC). | |||||||||||||||||||||
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Keywords
